Dmg Dimethylglycine Benefits
Review of Dimethylglycine (DMG)
Sep 17, 2019 Dosing considerations for Dimethylglycine. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). DMG 130 is back in stock increased energy levels. Improved neurological function and mental clarity. Better physical performance. Improved sexual function. Better cardiovascular health. Vastly improved immune system function, whilst inhibiting immune system response. Better cholesterol, blood. Once trimethylglycine work has been completed in decreasing homocysteine levels in the body, it becomes another substance known as DMG (dimethylglycine). In Russia, TMG/DMG is used extensively as an sporty performance enhancer, and it has also become popular among American athletes. Trimethylglycine Benefits. Trimethylglycine is a important aid to reduce homocysteine production and encourage normal heart and liver function. Kendall: DMG gives a wide range of specific health benefits, provides protection against infectious agents, and can optimize performance whether you are an athlete or have an active lifestyle. DMG aids cardiovascular function by improving oxygen utilization, reduces elevated cholesterol and triglyceride levels, decreases angina pain and high blood pressure.
What is Dimethylglycine (DMG)?
Dimethylglycine (DMG) is an amino acid that is found naturally, in small quantities in plant and animal cells. DMG is believed to improve endurance performance, enhance oxygen utilisation, and improve the rate of recovery. DMG is an anti-oxidant that may also works as a detoxifier.
Who Should Consider Taking DMG supplements?
DMG supplements may be of benefit to endurance athletes, or anyone, wanting to reduce their risk of infection through training.
Summary of DMG's Phyiological Effects:
- May enhance immune function but no conclusive evidence to support this
- Does not improve physical performance
- Doesn't appear to improve endurance performance or aerobic fitness
DMG Research
DMG has been proposed as a beneficial supplement, and is said to have been used medicinally to combat fatigue, enhance metabolism, improve liver function, and to strengthen the immune system (Tonda and Hart 1992). On the back of this some nutritional companies, have include DMG in their products, and made claims that it has beneficial effects on endurance performance by combating fatigue and enhancing the metabolism. However, there is at present, little evidence to back up these claims. In fact most research appears to point to there being little or no benefit to DMG supplementation.
Research looking at the effect of DMG supplementation in horses (Rose et al., 1989), found no beneficial effects of supplementation on measures of cardiac fitness or lactate production. Research in humans has proved to be equally ineffective. Liet et al., 2003 looked at the effects of DMG supplementation on measures of aerobic fitness in children suffering with cytochrome-c oxidase deficiency. They found that DMG supplementation had no detectable effect on blood levels of lactate, pyruvate, bicarbonate, pH, or measures of VO2.
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Research with humans has failed to find any positive benefits on measured physiological variables - specifically aerobic fitness - with DMG supplementation (100-200mg daily) (Harpaz et al., 1985; Bishop et al., 1987).
Research by Reap et al., (1989) found that DMG supplementation stimulated the immune system, and caused a four-fold increase in antibody production by the immune system. They found that there was no observed toxicity, or adverse effects during the treatment. However, this was an animal study and it cannot be assumed that the same results would be achieved in normal healthy humans.
Is DMG effective?
Some evidence supports it's use as an immune stimulant but it has proved ineffective at enhancing physical performance.
How to take DMG?
At present research does not support the use of DMG for athletes for improved endurance, or, enhanced immune function. However, most manufacturers, generally recommend taking around 100-200mg on a long term basis, which they claim reduces the risk of succumbing to illness or infection during intensified training. Or they suggest taking 200-300mg in the short-term (5-7 days) to possibly endurance performance leading up to a competition.
Athletes, or anyone, looking to enhance stamina, and immune function, will be better advised to use supplements like acetyl-L-carnitine – particularly if combined with alpha-lipoic acid, or, Rhodiola rosea.
References
Bishop, P. A., Smith, J. F. and Young, B. (1987) Effects of N' N'-dimethylglycine on physiological response and performance in trained runners. J Sports Med Phys Fitness. 27, 53.
Harpaz, M., Otto, R. M. and Smith, T. K. (1985) The effect of N' N'-dimethylglycine ingestion upon aerobic performance. Med Sci Sports Exerc. 17, 287.
Liet, J. M., Pelletier, V., Robinson, B. H., Laryea, M. D., Wendel, U., Morneau, S., Morin, C., Mitchell, G. and Lacroix, J. (2003) The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomised crossover clinical trial. J Pediatr. 142 (1), 62-66.
Reap, E. A. and Lawson, J. W. (1990) Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. 115 (4), 481-486.
Rose, R. J. Schlierf, H. A., Knight, P. K., Plummer, C., Davis, M. and Ray, S. P. (1989) Effects of N,N-dimethylglycine on cardiorespiratory function and lactate production in thoroughbred d horses performing incremental treadmill exercise. Vet Rec. 125 (10), 268-271.
Tonda, M. E. and Hart, L. L. (1992) N,N dimethylglycine and L-carnitine as performance enhancers in athletes. Annals of Pharmacotherapy. 26, 935-937.
Dmg Benefits And Side Effects
Dimethylglycine, also known as DMG, is a natural substance found in both plant and animal cells, and is derived from the amino acid glycine (see reference 1 under Clinical Summary para 1). As a supplement, it is purported to offer a number of health benefits, from enhancing physical performance to improving behavior in children with autism and attention deficit disorder. However, the evidence to support these claims is lacking, according to the Memorial Sloan Kettering Cancer Center (see reference 1 under Mechanism of Action).
How DMG Works
Best Dmg Supplement
The body produces DMG in the cells by breaking down choline (see reference 1 under Clinical Summary). In the body, it acts as an antioxidant and improves oxygenation of the cells (see reference 1 under Clinical Summary). The thought is that taking DMG as a supplement may further enhance oxygenation, which improves athletic performance (see reference 1 under Clinical Summary). It is also thought to act as a neurological stimulator, which is why it has gained popularity in the autism community (see reference 1 under Clinical Summary). According to an October 2009 review article on the use of complementary medicine in autism published in 'Child and Adolescent Psychiatric Clinics,' the two clinical trials testing the use of DMG on children with autism showed no positive effect or improvement in behavior (see reference 2 under DMG).
Safety Concerns
Dmg Dimethylglycine Benefits For Liver
DMG is considered a safe and non-toxic substance, according to MSKCC (see reference 1 under Clinical Summary). If you're supplementing your diet with DMG, be sure to inform your doctor to monitor for any potential side effects or interactions. Additionally, while it's safe to take DMG, do not rely on it as a cure or treatment for any illness.